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The study further shows that extended treatment duration elicits robust anti-fibrotic effects, consistent with the primary outcomes of the ESSENCE Phase 3 clinical trial, and recapitulates circulating biomarker signatures observed in semaglutide-treated MASH patients

GLP-1 medications alter digestion timing, and some supplement interactions can reduce absorption if taken together

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Novel therapies, including melatonin supplementation and modulation of the gut microbiome, are explored

Insulin sensitivity plays a role in weight change, with people who have poor sensitivity potentially benefiting more from drugs like tirzepatide, which can reduce HbA1c by as much as 2.4%