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Previous studies on melanocytes suggest that -catenin and LEF1 synergistically regulate the M promoter activity of MITF via LEF1 binding sites, which upregulate MITF expression in melanoma (27,28)

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doi: 10.4049/jimmunol.180.5.3447 28 HaringmanJJGerlagDMSmeetsTJBaetenDvan den BoschFBresnihanBet al