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In particular, VD analogs such as cholecalciferol, calcitriol, and paricalcitol demonstrated a significant improvement in renal function in two RCTs, possibly due to their ability to bypass the renal-dependent 1-alphahydroxylation process

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In a study with eight poorly controlled T2DM patients who received a liquid meal via a nasogastric tube and exogenous infusion of GLP-1 to achieve plasma levels of about 70 pM, gastric volume remained constant over 2 hours, and plasma glucose returned to normal fasting values within 3 4 hours (152)