10.3390/ijms21072351 53 RenX.SunL.WeiL.LiuJ.ZhuJ.YuQ.et al (2020)
Proc Natl Acad Sci 112(8):25092514 Pu J, Fang FF, Li XQ, Shu ZH, Jiang YP, Han T, Peng W, Zheng CJ (2016) Matrine exerts a strong anti-arthritic effect on type II collagen-induced arthritis in rats by inhibiting inflammatory responses
So for most, the warning does not apply
This randomized, double-blind, crossover clinical study evaluated 50 mg APS + 5 g L-arginine in 24 healthy adults (ages 2080), assessing arginine absorption pharmacokinetics (AUC, Cmax, Tmax), related amino acid metabolites (citrulline), and biomarkers associated with nitric oxide metabolism
They are not a shortcut or magic bullet they work best as part of a comprehensive plan that includes healthy eating, regular physical activity, and ongoing medical supervision