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Description

In 2016, concerns regarding retinopathy associated with GLP-1 were first raised in the Semaglutide Unabated Sustainability in Treatment of T2DM (SUSTAIN) 6 trial with semaglutide [89]

The GLP-1 agonists have other health benefits, alongside controlling blood glucose and weight loss

Hair thinning is a common, well-documented side effect of GLP-1 medications

11 Importantly, structural modifications to GLP-1RAs can prolong their half-life to 5-7 days compared to the 1-5 minute long half-life of endogenous GLP-1