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Store correctly: Once reconstituted, keep in the fridge (28 C)

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This provides a rationale for the effect of mutagenesis of R190 2.60 and K197 2.67 , which were two of the few TMD residues that had a large impact on exendin-P5 affinity (Supplementary Figs 5 and 9)

By binding to GLP-1 receptors in the pancreas, brain, and gastrointestinal tract, they enhance insulin secretion, suppress glucagon release, and promote satiety

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