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Last but not least, given the recency of these prescribing trends, no long-term data on the next-generation effects of these medications is available, leading to several uncertainties about the possibility and implications of long-term use

After oral administration of L-theanine, the metabolic activity of brown fat and subcutaneous white fat were increased, which significantly improved the obesity and hepatic steatosis of mice fed a high-fat diet (HFD), and the composition of intestinal microflora was also reasonably regulated (81)

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These results demonstrate that this pathway exerts a tonic inhibitory control over basal pain perception, in addition to its critical role in mediating fear-induced analgesia

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