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[10] [12] High-dose ascorbic acid may diminish the therapeutic effects of certain chemotherapeutic agents, such as bortezomib, due to its antioxidant properties
In the average adult, evening cortisol levels are low, falling to their lowest around midnight, and begin to increase around 4 AM, peaking in preparation for the day between approximately 7 9 AM
However, under pathological conditions, iron is readily involved a single electron transfer reaction and is transformed into ferrous iron, which shows high reactivity and toxicity
& Balduini, W
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