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[email protected] This article was submitted to Food Microbiology, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Abbreviations 4E-BP1: Eukaryotic translation initiation factor 4E-binding protein-1 6W: Six-minute walk test AEs: Adverse events BMI: Body mass index Comp: Composite endpoint DXA: Dual-energy X-ray absorptiometry ITT: Intent-to-treat LS: Lower strength MM: Muscle mass mTOR: Mammalian target of rapamycin MuRF1: Muscle RING-finger protein-1 NNHPD: Natural and non-prescription health products directorate NSAID: Non-steroidal anti-inflammatory drug PP: Per-protocol QoL: Quality of life S6K: p70-S6 kinase UPS: Ubiquitinproteasome system US: Upper strength References Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, Abellan Van KG, Andrieu S, Bauer J, Breuille D, Cederholm T, Chandler J, De MC, Donini L, Harris T, Kannt A, Keime GF, Onder G, Papanicolaou D, Rolland Y, Rooks D, Sieber C, Souhami E, Verlaan S, Zamboni M

It acts as a signal amplifier