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5-Amino-1MQ is a small-molecule NNMT inhibitor

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Practical management considerations include: Dose review: If the heart rate increase is dose-dependent and symptomatic, reducing the dose or slowing the titration schedule where permitted by the trial protocol may help mitigate the effect whilst preserving therapeutic benefit

Based on the budgetary impact of GLP-1 agonist spending, some employers considered changing their eligibility thresholds to reduce the number of enrollees who were potentially eligible