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However, we would suggest that future clinical trials should aim to assess the cost-effectiveness of screening older people with obesity who are undergoing weight management interventions for evidence of sarcopenia, through clinical evaluation including hand grip tests, which are accurate biomarkers for overall strength and function, bone mineral density and consequent fracture risk, and cardiometabolic disease [123]

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In clinical trial protocols, retatrutide followed a structured dose-escalation schedule designed to minimise gastrointestinal side effects the most commonly reported adverse effects with this class of medication

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