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Although the exact mechanism for this weight-reducing effect is unknown, the proposed mechanism includes alterated perception of taste due to carbonic anhydrase activity and modulation of dopamine and serotonin levels in the brain [241, 244, 245].Empatic has shown promising results in phase 2 clinical trials [241] (Table 2 )

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The items below are route-related and general-caution considerations, not a validated adverse-event list

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Scientists then traced the pathway responsible and found it was entirely separate from the tanning mechanism, rooted in melanocortin receptor activity in the hypothalamus (the brain region involved in regulating motivation and desire) rather than in the skin