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Adverse events were reported in 76.6% of the bremelanotide arm vs 58.2% placebo the difference driven almost entirely by expected pharmacological effects

Because these two pathways operate through different receptor systems and intracellular signalling cascades, they can have synergistic effects when studied in combination

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G., Molteni, R

Both compounds require subcutaneous administration for bioavailabilityoral forms degrade rapidly in gastric acid and hepatic first-pass metabolism