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The use of compounded drugs in patients using GLP-1s without medical supervision pose significant risk and can result in significant consequences, said Marina Basina, MD, a clinical professor in endocrinology, gerontology and metabolism

Microdosing can help individuals lose weight more slowly and is beneficial for those who want to lose small amounts of weight, such as 5-10 pounds, as slower progress can feel less overwhelming and is more sustainable

Pathophysiology of Facial Volume Loss with GLP-1 Medications The use of semaglutide and similar compounds leads to a reduction in overall body fat , including subcutaneous facial fat

Tripolino, C

Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism