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Tirzepatide has demonstrated superior efficacy in both weight loss and blood glucose control compared to semaglutide (Aronne et al., 2025), highlighting the therapeutic potential of multi-agonist strategies

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In the TRIUMPH-4 Phase 3 trial disclosed by Lilly in March last year, the share of participants experiencing nausea over 68 weeks of treatment was 38.1% in the 9mg group and 43.2% in the 12mg group