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Endo G and AIF move into the nucleus where they catalyze nuclear DNA fragmentation

4) Research on geneenvironment interactions is limited, as the synergistic effects of nutritional interventions and genetic backgrounds (e.g., PPARG polymorphisms) remain unquantified

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We treated human TC cells (K1, MDA-T68, MDA-T32, TPC1) with (1S,3R)-RSL3 (RSL3), a small-molecule inhibitor of GPX4 and examined the effects on ferroptosis, tumor cell survival and migration, spheroid formation, oxidative stress, DNA damage repair response, and mTOR signaling pathway in vitro

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