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Berberine may work well for: Article: PCSK9 variant with high LDL cholesterol: Berberine is a natural inhibitor of PCSK9 and has been shown in human studies[ref][ref] and cell studies[ref] to decrease cholesterol.For someone with variants that increase PCSK9 and increase cholesterol (below), berberine may be beneficial for lowering cholesterol

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Sticking to it is what matters