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148 These drugs act by simultaneously targeting three different agonists GLP-1R, the GIPR, and the GCGR

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experimental studies with other GLP-1 analogues (exendin-4 and liraglutide) have shown evidence of inhibition of oxidative stress, decreased apoptosis and prevalence of injured cells, decreased vascular proliferation, and increased c AMP levels in neurons and anti-inflammatory activity in microglial cells [67]