flow trial semaglutide kidney outcomes nejm 2024 hazard ratio 0.76

flow trial semaglutide kidney outcomes nejm 2024 hazard ratio 0.76 reduced the risk of clinically important and death from cardiovascular (CV) causes in patients with type 2 diabetes (T2D) and CKD ca. #ERA24 🇸🇪 #Nephpearls https://www.nejm .org/doi/full/10.1056/NEJMoa2403347 FLOWing with the SemagluTIDE —

Name: flow trial semaglutide kidney outcomes nejm 2024 hazard ratio 0.76 reduced the risk of clinically important and death from cardiovascular (CV) causes in patients with type 2 diabetes (T2D) and CKD ca. #ERA24 🇸🇪 #Nephpearls https://www.nejm .org/doi/full/10.1056/NEJMoa2403347 FLOWing with the SemagluTIDE —
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Mannavola F, Tucci M, Felici C, Stucci S, Silvestris F

Overdosing is a risk

Building on the findings from the SURMOUNT-OSA trial, which demonstrated tirzepatides efficacy in improving OSA in nondiabetic patients, this study investigated whether OSA modifies the mortality benefit associated with GLP-1 use among individuals with diabetes in a large, real-world population

& Charman, T

The pharmacokinetic properties including intestinal permeability, first-pass metabolism, microbiota-mediated biotransformation, plasma half-life, and systemic availability is essential for translational relevance

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