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However, unlike vitamin C and vitamin E, AMFK can donate more than one electron [90]

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NAIONs pathophysiology remains incompletely understood but involves vascular dysregulation, possibly exacerbated by drug-induced sympathetic nervous system changes and optic nerve head vulnerabilities such as a smaller Bruchs membrane opening

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The SYNERGY-NASH trial demonstrated that tirzepatide achieved MASH resolution in 44-62% of patients compared to 10% with placebo