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Microglia are also known to secrete GLP-1(Kappe et al., 2012)

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Interestingly, even though only 10% of subjects in EMPA-REG trial had a pre-existing HF at baseline, the positive effects on HF hospitalizations and cardiovascular death were consistent in patients with or without previous HF ( A previous meta-analysis including more than 34,000 diabetic patients, of whom 60% with established cardiovascular disease, showed that SGLT-2i reduced the incidence of MACEs by 11%, as well as the incidence of cardiovascular death and HF hospitalization by 23% (Zelniker et al., 2019)

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11 Metabolic disturbances are common in patients with ARDS