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They should not be used by: People with a history of pancreatitis (inflammation of the pancreas) Anyone with a personal or family history of medullary thyroid cancer (a rare type of thyroid cancer) People with multiple endocrine neoplasia type 2 (MEN 2, a rare inherited condition that raises the risk of certain hormone-related tumors, including thyroid cancer) Women who are pregnant or breastfeeding People with severe stomach or bowel problems, such as gastroparesis (slow stomach emptying that causes nausea, fullness, or vomiting) or inflammatory bowel disease (chronic inflammation of the digestive tract, such as Crohns disease or ulcerative colitis) Those with severe kidney problems, especially with certain types of GLP-1 medicines, such as exenatide Anyone with allergies to GLP-1 medications or who has had a severe reaction to them Use in children is limited to certain GLP-1 medicines approved for adolescents with obesity
Why Nausea Happens and What It Means When you first start on GLP-1 medications like Semaglutide, your gastrointestinal (GI) system needs time to adjust
This mechanism may be particularly relevant for patients who had significant insulin resistance before starting GLP-1 therapy
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It is not available on the NHS, holds no UK Summary of Product Characteristics, and any retatrutide outside formal clinical trials is classified as a research chemical
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