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In 2003, a clinical trial demonstrating prolonged survival of patients with metastatic colorectal cancer when chemotherapy was administrated in combination with humanized neutralizing antibodies targeting anti-vascular endothelial growth factor (VEGF) resulted in an FDA approval and provided proof-of-concept that anti-angiogenic therapy can be successfully used to treat cancer [4]

doi:10.1177/15563316251355551 Gwyer D, Wragg NM, Wilson SL

Sikiric et al., 2020b) (in various wound models, VEGF, factor VIII, CD34 peak appear in the early interval, while later depressed (Brcic et al., 2009))

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