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Clinical evidence demonstrates that L-carnitine supplementation reduces fasting blood glucose (53, 54), insulin levels (54, 55), glycated hemoglobin (HbA1c) (56, 57), and ameliorates insulin resistance (53, 54) in NAFLD patients

It is in vitro, on subcutaneous (not facial dermal) adipose stem cells, but it establishes the molecular plausibility of the mechanism subsequent reviews extrapolate to facial skin

10.1016/j.exger.2013.09.001 16 GuanL.GongD.YangS.ShenN.ZhangS.LiY.et al (2018)

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To achieve the maximum therapeutic effectiveness, rheumatologists recommend using combination therapy for RA patients (13, 14)