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These findings have changed guidelines on T2D management over the last years, and GLP-1RAs are now widely used in overweight patients with T2D as well as in patients with T2D and cardiovascular disease regardless of glycaemic control

Clinical Evidence Injection-site reactions and other adverse events must be interpreted from specific trial data

Mirtazapine Mirtazapine (Remeron) is associated with significant appetite stimulation and weight gain

Pregnancy: Discontinue semaglutide or tirzepatide at least 2 months before a planned pregnancy

The 2.5 mg starting dose usually produces mild appetite reduction and, for some patients, very little noticeable effect at all