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Johannes Mann presenting mediation analyses from SUSTAIN-6 and LEADER - about 25% of the treatment effect on the renal outcome in these CVOTs might be explained by glucose lowering #kidneywk Johannes Mann presenting mediation analyses from SUSTAIN-6 and LEADER - about 25% of the treatment effect on the renal outcome in these CVOTs might be explained by glucose lowering #kidneywk Modest reductions in BP and body weight might also contribute, but about half of the treatment effect remains unexplained, suggesting a direct effect of GLP1RA on the kidney #kidneywk Johannes Mann ending with a plug for the FLOW trial, the only dedicated renal outcome trial testing the effect of GLP1-RA (semaglutide) on a primary outcome of 50% decline in eGFR/ESKD/renal death #kidneywk

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