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Additionally, it reduces melanin production by inhibiting tyrosinase enzyme, leading to brighter skin tone

TMAO also activates the inflammatory response by inducing the expression of IL-6, cyclooxygenase-2 (COX-2), endothelial selectin, and intercellular cell adhesion molecule-1 (ICAM-1), which enhances macrophage adhesion through protein kinase C (PKC) and NF-B signaling pathway

the subject in need thereof may be identified as being a responder, or a subject particularly likely to benefit from treatment, based on the subject having an abnormal or poor score on at least one of the following behavioural assessments: CARS behaviour T-Score

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2025 Aug