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The affinity ( k d ) and fraction unbound were determined using the 1:1 binding model

In mammals, this temporal coordination is achieved through a hierarchical circadian timing system composed of a master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus and multiple peripheral clocks distributed across metabolic organs, including the liver (22, 23)

If your next dose is sooner than that, skip the missed dose and resume your regular schedule

Finally, if there is a concern of retained gastric contents, shared decision making with the patient and care team should be used to determine risk vs benefit of delaying the procedure vs rapid sequence induction and tracheal intubation