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The SWITCH-SEMA 2 study [121] randomized 174 participants with DM2 who were receiving medication with a dipeptidyl peptidase-4 inhibitor (DPP-4i) to either continue their protocol with DPP-4i or switch to oral SMG (initial doses of 3 mg progressing to 14 mg per day)

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The progressive form, MASH, exhibits hepatocyte damage, inflammatory cell infiltration, and variable degrees of tissue fibrosis, with advanced fibrosis representing the predominant prognostic determinant for hepatic morbidity and mortality, as well as an additional risk factor for extrahepatic complications