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Table 1 Clinical trials with GLP-1RAs in NAFLD

Unknown Risks: Given its influence on fundamental metabolic processes (AMPK) and mTOR regulation, the long-term safety of chronic, supraphysiological MOTS-c administration is unknown and requires caution

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Glutathione inhibits tyrosinase, an enzyme in melanin production, which can gradually lead to more even skin tone and reduced dark spots

By reducing the urge to eat excessively or make poor food choices, Semaglutide can help patients adopt healthier eating patterns, which are crucial for long-term disease management and overall health