As a result, methylation may be disrupted, leading to a range of health issues, including mood disorders associated with undermethylation and copper overload
Material and Methods For this narrative review, we searched for articles published in PubMed and Google Scholar between January 1, 1990 and March 2022 using the keywords oral, systemic treatment, treatment, therapy, skin aging, photoaging, oral collagen, isotretinoin, tranexamic acid, Polypodium leucotomos, niacinamide, antioxidants, metformin, hormonal replacement therapy, melatonin, flavonoids, vitamin, vitamin C, vitamin E, vitamin D, senolytics, hyaluronan, hyaluronic acid, glucosamine, coenzyme Q10, glutathione, marine complex, pine bark extract, food supplements, aloe vera, and Hydrangea serrata
Excitation wavelength: 488 nm, Exposure time: 400 ms, gain: 0
Deficiency of vitamin B-12 can lead to abnormal neurologic and psychiatric symptoms including ataxia (shaky movements and unsteady gait), muscle weakness, spasticity, incontinence, hypotension, vision problems, dementia, psychoses, and mood disturbances.
doi: 10.1126/sciadv.adq6038 387 WuY.XieL