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One observed a positive association between liraglutide use at 12 weeks and improved MMSE in 47 adults with T2DM, which correlated with increased task (verbal fluency)-based activation of the dorso-lateral prefrontal and orbitofrontal cortex, while several other cognitive tests were not affected 45

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Comparator groups and exposure definitions also varied across studies, and prescription records did not always confirm that the medications were taken

Because these therapies serve different purposes, they may complement each other as part of a broader treatment plan

The right next step depends on the reader's evidence, safety, cost, access, and provider-review needs