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Butyrate serves as a primary energy source for colonocytes and enhances intestinal barrier integrity by increasing the expression of tight junction proteins like occludin, which is vital for preventing systemic inflammation 34

Consequently, we suggest that numerous apparently inaccurate online data base annotations may underestimate the true extent of metazoan PRX diversity, and we predict that a greater breadth of PRX research will reveal further lineage-specific PRXs