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Anesthesiology 105:599612

Minshall, R

Abbreviations IGF-1: Insulin-like growth factor-1 GFBP 15 : Insulin-like growth factor binding proteins 15 BrCa: Breast cancer GH: Growth hormone IRS-1: Insulin receptor substrate 1 PI3K: Phosphatidylinositol 3-kinase MAPK: Mitogen-activated protein kinase ER-: Estrogen receptor - PR: Progesterone receptor SUMO: Small ubiquitin-like modifier BRCA1: Breast cancer 1-early onset protein KLF6: Kruppel-like factor 6 PARP1: Poly-ADP ribose polymerase 1 VHL: Von hippel lindau protein WT1: Wilms tumor 1 protein S6K1: Ribosomal protein S6 kinase 1 protein mTOR: Mammalian target of rapamyci HER2: Human epidermal growth factor receptor 2 protein SNP: Single-nucleotide polymorphism PBS: Phosphate buffer saline EMT: Epithelial to mesenchymal transition CTCs: Circulating tumor cells ECM: Extracellular matrix BD: Binding domain VEGFc: Vascular endothelial growth factor receptor c EGFR: Epidermal growth factor receptor TGF: Transforming growth factor UTRs: Untranslated regions EREL: Estrogen-responsive element-like site PGE2: Prostaglandin E2 ChIP: Chromatin immunoprecipitation COX-2: Cyclooxygenase-2 VN: Vitronectin ECR: Evolutionary conserved regions DFS: Disease-free survival TDLU's: Terminal duct lobular units BCSC: Breast cancer stem cell BCSS: BrCa-specific survival mAb: Monoclonal antibody RTKI: Receptor tyrosine kinase inhibitor IR: Insulin receptor References Ruan W, Kleinberg DL

The belly button is saved and brought through the abdominal skin and placed in the normal position

Prolonged Satiety Slows digestion to help you feel full longer after meals Support Metabolic Health Helps regulate blood sugar and insulin response, key to long-term weight management