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Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

PRP requires blood draw and processing, typically performed in medical settings at considerable cost

These pretreatment differences reduce the power of the pooled analysis (more for EI than TEE)

Each treatment targets a different mechanism, and the right combination depends on the patients biology

Recording pipettes were pulled (Sutter, P-1000) from borosilicate glass capillaries (1.5 OD 1.17 100 L mm, Harvard Apparatus) and fire polished with an in-house developed microforge to reduce the tip diameter and get pipettes with resistance between 23 Mega ohms