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It discusses the pathophysiology of APAP metabolism, where the production of the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI) leads to hepatotoxicity when consumed in excessive doses

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Red blood cell formation and oxygen transport

To enhance its bioavailability, drug delivery systems including emulsions, nanostructured lipids, hydrogels, and liposomes have been recommended and employed with some success including improved chemical stability, better penetrability, and enhanced bioactivity [144, 153,154,155,156]

This negates the need for additives such as lidocaine or expensive protocols that include EMLA cream (to numb the skin)