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Further elucidation is needed about the function of tanycytes and tanycytic GLP-1R-dependent transport of GLP-1RAs

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As discussed above, endogenous GLP-1 is rapidly degraded by DPP-4, whereby it loses its insulinotropic activity, and preventing this degradation results in increased intact GLP-1 levels, improved pancreatic islet responses (enhanced insulin and suppressed glucagon levels) and beneficial effects on glucose homeostasis

Yes, B12 injections are safe and often prescribed when oral supplementation isnt effective [*]