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To advance translational applications, future studies should focus on: (1) transforming dynamic biomarkers into clinical decision-making tools, such as evaluating early changes in circulating mitochondrial-derived vesicles or oxidative stress markers (e.g., 8isoprostaglandin F2 (8-iso-PGF2))to predict subsequent biochemical and histological responses

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These alterations impair nutrient absorption, reduce the bioavailability of amino acids including leucine, and contribute to chronic low-grade inflammation that exacerbates anabolic resistance and endothelial dysfunction