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Across phenotypes, our data indicate an association between rs1800437 and tirzepatide treatment for both the vomiting and nausea phenotypes, and potentially constipation, but the variant does not seem to influence efficacy ( P = 0.73

Experiencing side effects during IGF1 LR3 research needs prompt recognition, appropriate response, and clear communication with research supervisors or medical personnel

The numbers in parentheses show the contribution rates

Potential candidates may include adults with: Type 2 diabetes Obesity Overweight with weight-related medical conditions Elevated cardiovascular risk Treatment decisions should always be individualized

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