fda compounded glp-1 Pharmacovigilance Assessment of Receptor Agonists: Insights From the Adverse Event Reporting System Compounded GLP-1 Drugs and its

These factors, combined with the continuous rise in diabetes and obesity rates and the anticipated economic burden of such conditions, are expected to drive up the demand for relevant treatments or prevention methods

Improved Glycemic Control : By increasing insulin secretion and decreasing glucagon levels, GLP-1 medications help regulate blood sugar levels, making them especially beneficial for individuals with type 2 diabetes

The LEADER trial with liraglutide reported a reduction in MACE (HR 0.87), while the REWIND trial with dulaglutide demonstrated an HR of 0.88

doi: 10.3390/molecules24081583 174

For this purpose, activation of adaptive stress responses was investigated for DNA damage (p21), oxidative stress (SRXN1), inflammation (ICAMI), and ER stress (CHOP) using a HepG2-based GFP-reporter assay (Wink et al., 2014, 2017)