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Structurally, the C6-C3-C6 backbone serves as the fundamental scaffold for the biological activities of flavonoids, while different subclasses, including flavones, flavonols, flavanones, and isoflavones, exhibit distinct functional characteristics due to variations in their molecular structures

The C3 component can be either an aliphatic chain or part of a five- or six-membered oxygen-containing ring with C6 segments

Another randomized controlled trial included 95 patients with migraine with aura who received 5 mg of folic acid plus 80 mg of B6, folic acid alone, or placebo daily for three months

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