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Consequently, a perfect storm of conditions can develop that pushes the pre-existing condition of low oxygen tension in the kidney into the realm of hypoxia (figure 1)

Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy

According to the regulatory guidelines, it is also pinpointed that development should consider immunogenicity and impairment of organs, including renal and hepatic function, which may affect drug metabolism and safety

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