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Because the body's stress response runs through the hypothalamic-pituitary-adrenal axis, support that helps the brain stay clear under pressure may make that response feel more manageable, a stress cascade described in detail by Harvard Health Publishing

Microglia with depleted GSH have an exacerbated ROS/RNS production, elevated pro-inflammatory cytokine release, impaired phagocytic clearance, and increased neurotoxic output ( As discussed, the interplay between astrocytes and microglia via modulation of GSH activity implies that GSH is not only a cellular antioxidant, but an important mediator of cross-talk between resident CNS immune cells

Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers

When it comes to glutathione, dosage determines outcome

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