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The EMA stated that NAION may affect up to 1 in 10,000 people taking semaglutide and recommended that semaglutide treatment be stopped if NAION is confirmed

In untreated controls, this hypoosmotic shock results in the transient enlargement of cells due to increased turgor, with typical cytoplasmic volume increases of less than ~5% 41 , as confirmed here (Supplementary Movie 8)

Wegovy is administered as a once-weekly subcutaneous injection, with doses gradually increased over 1620 weeks to the maintenance dose of 2.4 mg (or 1.7 mg if the higher dose is not tolerated)

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