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Cu + and Fe 2+ can convert H 2 O 2 to a highly reactive hydroxyl radical (Fenton reaction), which locally damages various biomolecules at the site of its formation

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Six-week intraperitoneal injection of SPD and resistance training increase the p-AMPK/AMPK ratio and FOXO3a protein expression in skeletal muscle of D-galactose (D-gal)-induce senescent muscular dystrophy rats, activate the AMPK-FOXO3a signaling pathway, upregulate the levels of Beclin1 protein and the LC3-II/LC3-I ratio, and downregulate those of the p62 protein