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It activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, ODonnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME (2008) A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation

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Despite the lack of a single established biomarker of disease progression in PD, recommendations on outcome measures for trials of DMT in PD have been published [50], with the aim of helping homogenise clinical research in PD, thus enhancing comparability of trial results