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When ascorbic acid contacts copper, a reduction reaction occurs

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In addition, if you're one of the millions of Americans taking proton pump inhibitors (PPIs) that suppress stomach acid for conditions like acid reflux, you're going to be prone to vitamin B12 deficiency

While its true that receptor density can change due to various factors, its an oversimplification to suggest that this change is the direct cause of increased pain or sensations in B12-treated individuals