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Various pharmaceuticals, including erastin and RSL3, provoke ferroptosis by diminishing glutathione peroxidase 4 (GPX4) activity, facilitating the accumulation of lipid peroxides [88]

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Under low-iron conditions, IRPs bind to IREs in the untranslated regions (UTRs) of target mRNAs, stabilizing TfR1 and DMT1 transcripts while suppressing translation of ferritin and FPN1

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