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Signs and Symptoms of Heavy Metal Poisoning Some of the most common warning signs that you might be struggling with heavy metal toxicity include: Chronic fatigue Autoimmune diseases, including Lyme disease Poor recovery from exercise and weakness Skin irritation Neurological disorders Brain fog, trouble concentrating, difficulty learning and poor memory Depression, manic depression and/or anxiety Dementia Insomnia Digestive issues, such as irritable bowel syndrome Chronic aches and pains, such as those associated with fibromyalgia Tremors Impaired motor control, hearing, speech, vision and gait Anemia Higher risk for heart attacks Where Do Heavy Metals Come From