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Ablation of myt-1 significantly reduced the longevity of eat-2(ad1116) mutants, suggesting that it was partially indispensable for life span extension due to dietary restriction (Figure 8B and Supplemental Figure 6A), but with a smaller effect size compared with its effect on WT worms, as confirmed by Cox proportional hazards (CPH) analysis ( P = 0.00004)

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Benefits of lixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide, versus insulin glargine and lixisenatide monocomponents in type 2 diabetes inadequately controlled with oral agents: the lixiLan-O randomized trial